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October 2010 physicians, psychologists and social scientists form research network against child abuse
The Federal Ministry of Education and Research (BMBF) provides a total of 32 million euros for research projects on the extent, causes and consequences of abuse and violence in childhood and adolescence are available. "Violence and abuse against children and adolescents has been little scientific research," Federal Research Minister. "We urgently need reliable information on the abuse, neglect and violence against children. We expect that an important foundation to prevent child abuse and the victims to provide effective help," said Federal Minister for Research Annette Schavan.


In an interdisciplinary research network "abuse, neglect and violence" will work together the best scientists in Germany from the medical, psychological and social science research. The aim is to develop measures to improve prevention of violence against children and for effective treatment of those affected. The BMBF will provide this research network of around 20 million euros. "We hope that a systematic findings on the reasons, people to violence against children and young people move, and the physical and psychological effects of abuse and neglect in childhood, "says Annette Schavan.

also for promoting education of scientific research additional funding. The main goal in the field of educational research is to research areas to vote and research networks set up. By expanding the knowledge base, the initial, -. and training on dealing with abuse cases makes sense to be developed and expanded

To improve the data base is to support the Federal Ministry for Education and Research, an update and expansion of the only German representative survey of 1992 on the topic of sexual abuse of children. Like 1992, the Criminology Research Institute of Lower Saxony (KFN) to realize this project. The sample is increased, however, this time of 3,300 to 10,000 persons and the age group of 16 - to 40-year-olds are limited

Prof. Dr. Christian Pfeiffer, director of KFN and head of the investigation, said: "We have currently in Germany neither current, representative and scientific evidence concerning the actual extent of child sexual abuse nor to the specific risk constellations of its formation. Thanks to the favorable environment for the new survey, we are now able to better clarify which children are at particularly high risk of abuse of the persons the greatest hazard in and promise the preventive approaches success. "

by the Federal Ministry of Research, initiated measures are part of the activities of the Roundtable" Child sexual abuse in dependency and power relations in private and public facilities and in the family "of the federal government. Together with Federal Family Minister Kristina Schroeder and Justice Minister Sabine Leutheusser-Schnarrenberger consists Schavan it for better protection of children and young people from sexual violence. The 2nd meeting of the Roundtable held on 30 September 2010 in Berlin.

more information at:
www.rundertisch-kindesmissbrauch.de/
Federal Ministry for Education and Research
news of 29.09.2010

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mouse with human immune

New method to study and treat diseases facilitate

If common medicines no longer act, can offer the use of antibodies against the pathogen is an alternative. Antibodies in the blood of animals such as mice, can not yet use it: The human immune system recognizes them as foreign and rejects them. Scientists at the Helmholtz Centre for Infection Research (HZI) in Braunschweig is now in an international cooperation a promising approach succeeded: With the help of stem cells, they brought mice to form an immune system with human immune cells - which also produces human antibodies. These immune molecules could serve the research and treatment of human diseases. The researchers published their results in the online edition of Science magazine PLoSOne.


Antibodies are small proteins that are produced by B cells during an immune response. They bind to invading pathogens and mark them by, so that macrophages can recognize and kill the germs. "Our immune system distinguishes between foreign and body's structures - that his job is, "said Professor Carlos A. Guzman, head of the Department of Vaccinology and Applied Microbiology" at the HZI. "Unfortunately, the consequence that come to an antibody therapy exclusively human antibodies in question." In mice formed antibodies to the human immune system, fights by turn produces its own antibodies against them - a danger for the patient. Moreover, it is very difficult to change from the mouse antibodies for use in humans or antibody producing cells to isolate from human and alive.


To equip
mice with a human immune system, the scientists used an already established process: They injected human stem cells in young mice, which due to a severe genetic defect, no immune cells. The stem cells migrate into the bone marrow of young animals, proliferate and form a human immune system in mice. "In our subsequent studies we could find all important immune cell types in mice," said Dr. Pablo Becker, a scientist in the HZI Department of Vaccinology and Applied Microbiology.



To investigate the immune response, the researchers vaccinated mice against hepatitis B or tetanus. Antibody-producing B-cells indicate this as well and is successful, the immune response. The researchers isolated these cells and treated them so that they can survive outside the body in the cell culture dish and continue to produce antibodies. Subsequently, the researchers examined the antibodies. The result can hope: "The antibodies in the test show good properties, but must be improved for use in humans yet," says Becker. "We could, however, first to show that it is possible to obtain human antibodies from mice." It is now important to develop this mouse model further to make it one day encourage the development of therapies for diseases to be able to. "In the future," Becker also hopes, "could these mice are used to develop therapeutic antibodies for the clinic."

source Helmholtz Centre for Infection Research