08/27/2010 Scientists at the Paul Flechsig Institute for Brain Research, Department of Molecular and cellular mechanisms of neurodegeneration, the University of Leipzig have found evidence that the degenerative Alzheimer's disease a result of a brain development disorder. "Alzheimer's seems to be innate, in fact," is how Prof. Dr. Thomas Arendt recent research that now in the journal The American Journal of Pathology were described.
According to Arendt called hyperploid neurons are responsible for ensuring that die in Alzheimer's disease brain cells in large numbers. "In the development of stem cells to neurons, there is actually a mechanism that allows die such 'false' Blocks'," said Arendt. In the hyperploid neurons - in contrast to healthy cells - instead of two pairs of chromosomes a variety of genetic inheritance support available. "Some take four or even six other pairs of chromosomes," says the brain researcher. Since there are numerous combinations of such cells, they also speak of a mosaic. "These mosaics are also in the normally developed adult brain healthy available, "said Arendt.
According to the Alzheimer's expert at the Paul Flechsig Institute, the human system can apparently handle a certain number of hyperploid cells in the brain well, and they tolerate." In the brain of Alzheimer's patients but we twice as many resistant;. it seems to be broken through a tolerance limit, "says Arendt, the problem is that Hyperploidie is an irreversible process, the affected cells die in any case, just as if a not in brain development undertaken. regulation will be rescheduled Determined
have the brain the researchers in the study of samples from brains of people with varying degrees of Alzheimer's disease.: If the hyperploid cells in the normal brain only available in limited numbers, so their numbers increase in pre-clinical phase of the disease and for the period in which only mild effects are identifiable, clearly. When difficult patients suffering from Alzheimer's disease however, falls again, the number of hyperploid cells. "A clear indication that they are dead, because cells do not simply disappear like this."
From now present findings of scientists can derive a number of new issues. "Why is a hyperploid cell as susceptible to cell death? Is this failure has also detectable in other organs than the brain? Is there also harmful influences on mother and child during pregnancy, leading to the developmental disorder of the brain? "says Thomas Arendt only a few possible approaches. quick answers but there was no question, he warned against exaggerated expectations.
source Universität Leipzig
0 comments:
Post a Comment