09/07/2010 A small child who suffers at night scratching himself bloody, possibly in an atopic dermatitis. The extreme itching is typical of these, also known as atopic skin disease. The disease often occurs during infancy on - and is currently in the developed on the rise. The skin of neurodermatitis is very sensitive and reacts strongly to external stimuli. A team at the LMU researchers Dr. Astrid Peters and Professor Katja Radon accompanied now almost 4000 subjects from childhood to adulthood and asked about atopic diseases and possible environmental and occupational exposure.
"We have the basis of data prediction models developed for puberty, because this phase in the disease process is often important," says radon. "It was found that the most important risk factor for juvenile dermatitis sufferers of occupational contact with certain substances, such as bakers flour or disinfectant. This Results provide the allergist a tool to better advise the patient to hand - especially in terms of career choice "(Journal of Allergy and Clinical Immunology online, 7 September 2010)
A neurodermatitis is stressful -. For the young patients as also for their parents. Because of the extreme itching often leads to the fact that the children scratching himself bloody, while the inflamed skin may become infected. Atopic eczema, atopic dermatitis is how the medical is assigned to the allergic diseases. The disorder probably results from the interaction of genetic and environmental factors. For example, tobacco smoke and house dust as risk factors detected, while siblings or other contact with other children a positive impact. Atopic dermatitis is in developed countries on the rise and concerns by some estimates up to 20 percent of European children.
occurs frequently Kopp already in young children, may disappear in later years but also of their own accord. A critical stage in the disease process is often at puberty. Some stakeholders heal spontaneously during this period, whereas at the other to a significant deterioration. "It is known that occupational factors play a role," says radon. "But there was no possibility of the progression of the disease in later years to predict with a certain probability. We have, therefore, the data from existing studies on asthma and allergies used to track the progress of atopic dermatitis during puberty, to identify possible risk factors. - And to model the individual development "
The data of 4000 subjects included in The investigation, which was sponsored by the Federal Ministry of Labour and Social Affairs and the Federal Institute for Occupational Safety and Health. This allowed the natural course of atopic dermatitis at the age of 9-11 and 16-20 years are determined. Furthermore, relevant risk factors in terms of the occurrence, recurrence or the existence of the disease during adolescence assessed. About seven percent of participants developed atopic dermatitis only in their youth. Girls had a higher risk of developing in the teenage years, while among the children are increasingly affected boys. As expected, a pre-existing atopic dermatitis was found in close relatives as a strong risk factor.
"was also important for us, but that risk factors lose in infant and childhood in general significantly to influence," says Peters. "This includes, among other things, that a child was not breast fed, has no siblings, and attended a kindergarten. In adolescence seems only the occupational contact to be particularly important to irritating substances. "Among the high-risk jobs are counted work in the bakery, as a cleaner or in nursing. "The effect of exposure in such occupations, even negative, if it is temporary or for a short time," said Peters. "Should consider Allergists these results when considering neurodermatitis or according to vulnerable young people in their career choice." (Suwe)
Source Information Wissenschaft idw
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